Early sarcomatous changes in Paget's disease of bone.

Early sarcomatous changes in Paget's disease of bone.

SARCOMA is a well-recognized complication of Paget's disease of bone and surgeons are constantly on the alert for malignant changes in this disease (Lake, 1951; Poretta, Dahlin & Janes, 1957; Barry, 1961; Price, 1962). The case which is the subject of the present report has some unusual features which are of interest from both the clinical and pathological points of view particularly as the sar...

Pagets Disease Of The Nipple

Pagets disease of uncertain origin: case report

BACKGROUND Pagets disease of the nipple presents as an eczematous lesion, occurs in 1 - 4% of all female breast carcinoma cases and is invariably associated with underlying malignancy either overt or occult. The majority of these cases are invasive disease although 40-45% are associated with DCIS. CASE PRESENTATION A 39 year old lady presented to our unit with a palpable lump in the right bre...

Intrahepatic Cholangiocarcinoma with Sarcomatous Changes

A 61-year-old Japanese male was seen at an outside hospital with abdominal pain and distention. An intraabdominal mass was found on abdominal computed tomography (CT), and he was referred for further evaluation. He was afebrile, with mild tenderness in the upper abdomen and massive distention. Routine blood work showed severe inflammation and anemia. Repeat CT showed a large solitary heterogene...

99mTc-MIBI scan in mammary Pagets disease: a case report.

Technetium-99m methoxyisobutylisonitrile (99mTc-MIBI) uptake is known to be increased in breast cancer because of increased blood flow from angiogenesis and heightened metabolism. We performed a 99mTc-MIBI scan in a patient with mammary Paget's disease. The patient had underlying invasive cancer in the same side of the breast. 99mTc-MIBI scan exhibited a scintigraphic image of the uptake from t...